Author: Docker, P.
Paper Title Page
The Use of Vibration to Achieve Precision  
  • P. Docker
    DLS, Oxfordshire, United Kingdom
  The work here describes how vibration and the acoustics it produces have been embraced to achieve precision in the macro, micro, nano and pico regime. On the macro scale it has been harnessed to develop smart structures that use resonance and its subsequently high Q to accurately determine positioning and preloads on assemblies. These structures can be machined into support assemblies to ensure consistency in the results they produce as they are integral and never removed. This ensures the data they give is directly comparable pre and post service. The high Q they offer promises new levels of accuracy in assembly and a potential for an audit trail. The other application this work describes is the use of vibration to generate acoustic levitation for room temperature and time resolved sample delivery encompassing the micro, nano and pico regimes. Our methodology moves away from traditional Langevin horn cavities used by previous workers for levitation experiments to low power tractor beam ones specifically designed for light source applications. This has been complimented with the exciting technology of Poly Pico who can use acoustics to eject sample droplets in the order of 10 picolitres and at a rate of 50 kHz and on demand. These two technologies compliment each other beautifully for mixing experiments facilitating ’watching’ reactions taking place within a protein. Finally work describing how TEM grids can be filled for CryoEM using the Polypico technology and electro-steering to remove the need for any moving parts delivering discrete sample aliquots and at kHz time scales with micron accuracy.  
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