Author: Sherrell, D.A.
Paper Title Page
Nylon Mesh Holder for Serial Crystallography Experiments  
  • D.A. Sherrell
    ANL, Lemont, Illinois, USA
  Funding: Work supported by the U.S. Department of Energy, Office of Science under Control DE-AC02-06CH11357.
Over the last two years, we have developed a 3D printed nylon mesh holder for serial synchrotron crystallography (SSX) experiments. We are moving away from the complications in some devices to a cheap, easy, and user-friendly format. The device uses a new, patented*, two-layer (one rigid and one flexible) substrate technique developed at Argonne. The SSX device and method, which incorporates a modular high-performance computing data analysis backend, was used to demonstrate never-before-seen molecular dynamics** and discovered the methylated form of the SARS-CoV-2 Nsp10/16 protein*** complex. Named ALEX (Advanced Lightweight Encapsulation for Crystallography) for short, we are actively using, upgrading, and reaching out to collaborators. We are using ALEX for serial experiments at APS but feel the design might be useful for other applications.
* Patent #16/903, 601
** Currently in writing stage
*** Accepted for publication
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